Feline immunodeficiency virus and feline leukemia virus cause significant welfare harm and are preventable through vaccination and management.
FIV and FeLV cause significant welfare harm through immunosuppression that allows opportunistic infections and neoplasia. Prevention through neutering to reduce fighting, keeping cats indoors in high-risk areas, FeLV vaccination, and testing before introduction to multi-cat households prevents most transmission. Cats diagnosed with FIV or FeLV can still have good welfare with appropriate management and veterinary support.