Red squirrels have been largely replaced by introduced grey squirrels across England and Wales, and their survival depends on targeted grey squirrel control and disease management.
Red squirrels in areas with grey squirrel incursion face mortality from squirrelpox, a disease causing lesions around the eyes, mouth and feet before death. Competition reduces food access and territory quality. Individual red squirrels removed from protected areas by disease experience prolonged suffering from the virus.