Mastitis is the most costly and common disease in dairy cows, causing significant pain and welfare harm to millions of cows annually worldwide.
Dairy cows with clinical mastitis experience acute pain from inflamed udder tissue, fever, and systemic illness that reduces feed intake and social behaviour. Severe E. coli mastitis causing septicaemia is extremely painful and rapidly fatal without prompt treatment. Chronic subclinical mastitis, while less acutely painful, causes ongoing discomfort during milking and chronic immune activation. The scale of mastitis in dairy herds means millions of cows globally experience udder pain each year, making it one of the most significant farm animal welfare problems by total suffering burden.