The black-footed ferret is North America most endangered mammal and a conservation success story in progress.
Black-footed ferrets in captive breeding programs face unique welfare challenges. Maintaining natural hunting behaviors requires live prey exposure, which must be balanced with prey welfare. Ferrets are highly active and need complex environments to prevent psychological stagnation. Reintroduced ferrets face significant mortality from predation and disease. Oral plague vaccines are now being distributed via food baits to protect prairie dogs and ferrets alike.