Mice and rats make up over 95% of research animals but have fewer legal protections than other species.
Laboratory mice and rats experience significant suffering from research procedures, yet receive the least legal protection of any commonly used research species. Enriched housing — with nesting material, tunnels, and social companions — dramatically improves rodent welfare and has been shown to improve research quality and reproducibility. Extending legal protections to mice and rats would require ethical review of their use and incentivize welfare improvements without eliminating necessary research.