Research Animals

Animal Experimentation Alternatives Development

The 3Rs framework — Replace, Reduce, Refine — drives development of alternatives to animal experimentation.

Key Facts

In vitro methods, organoids, and computer models are replacing many animal tests
The EU has committed to phasing out animal testing through REACH chemical regulations
Organ-on-chip technology replicates human tissue responses more accurately than animal models
The gap between available alternatives and their adoption in testing remains significant

Welfare Considerations

The development and adoption of alternatives to animal testing is one of the most important welfare science frontiers. New approach methodologies (NAMs) including organoids, microphysiological systems, and computer modeling increasingly outperform animal models for human relevance. Regulatory acceptance of alternatives lags behind their scientific validation, creating unnecessary continued animal use.

What You Can Do

Support organizations developing and validating alternatives to animal testing
Advocate for accelerated regulatory acceptance of validated alternative methods
Choose products from companies investing in non-animal testing methods
Support funding for alternatives development through relevant charitable giving