Laboratory animal welfare is governed by regulations requiring harm minimisation, but implementation varies widely and millions of animals still suffer in research settings annually.
The ethical justification for animal research depends on necessity, harm minimisation, and the validity of animal models. Where animal research is permitted, strong welfare standards including pain management, enrichment, social housing, and humane endpoints are non-negotiable. Advocates should push for full implementation of the 3Rs, accelerated development of alternatives, and transparent reporting of animal use and welfare outcomes.