Guinea pigs have been used in biomedical research for centuries and remain important models in immunology and infectious disease, with specific welfare requirements for their social and dietary needs.
Guinea pigs used in research face welfare challenges specific to their social and physiological biology. Single housing, which was once standard, causes measurable psychological distress and affects experimental results — a double harm. Their prey animal status means handling by humans is inherently stressful, and poor handling technique causes fear that compounds over repeated procedures. Vitamin C deficiency from inadequate diet causes scurvy, which is painful and entirely preventable. Refinements in housing, handling, and husbandry can significantly reduce suffering without compromising scientific validity.