Hyperadrenocorticism, or Cushing's disease, is a common hormonal disorder in middle-aged to older dogs that causes progressive, systemic suffering if undiagnosed and untreated. Effective management significantly improves quality of life.
Cushing's disease causes a constellation of chronic, uncomfortable symptoms that significantly reduce quality of life. Constant thirst and urination are socially disruptive and cause anxiety if dogs cannot access water or outside. Muscle weakness and pot belly reduce mobility and exercise tolerance. Skin thinning, hair loss, and calcinosis cutis (calcium deposits under skin) cause physical discomfort. The slow onset means many dogs suffer for years before diagnosis. Trilostane treatment effectively reduces cortisol levels and resolves clinical signs in most dogs, but requires careful monitoring — adrenal suppression can cause dangerous hypoadrenocorticism (Addisonian crisis). Well-managed dogs experience dramatic quality-of-life improvements. Regular monitoring every 3-6 months is essential for safe, long-term control.