Radioactive iodine therapy is the gold standard treatment for feline hyperthyroidism, providing a permanent cure with a single outpatient treatment.
Radioactive iodine offers feline hyperthyroid cats a permanent cure with a single, minimally invasive treatment. The main welfare consideration is the post-treatment isolation period — cats must be confined to prevent radiation exposure to owners and other animals. This isolation causes stress, particularly for social cats. However, the alternative of lifetime daily medication is often more welfare-costly overall — medication compliance is poor, and untreated or undertreated hyperthyroidism causes progressive organ damage. For cats with good life expectancy, I-131 treatment provides the best long-term welfare outcome.