Liver fluke infection is a major cause of sheep mortality and welfare harm worldwide. Changing climate patterns are expanding its range, requiring updated control strategies.
Liver fluke causes significant welfare harm at multiple stages — acute disease causes sudden death after a period of severe liver destruction; chronic disease causes prolonged debility, pain, and reduced quality of life. Subclinical infection suppresses immune function, allowing other diseases to establish more easily. Resistance to triclabendazole means that in some regions, effective treatment options are limited, threatening flocks with progressive welfare harm. Integrated control strategies (drainage, snail habitat management, targeted treatment, and strategic use of different flukicide classes) are essential.