Antibiotic use in aquaculture can both improve fish welfare by treating bacterial disease and threaten it through contribution to antimicrobial resistance.
Antibiotic use in aquaculture presents a welfare paradox. Treating bacterial infections relieves pain and prevents death, benefiting fish welfare in the short term. But overuse and prophylactic use drive resistance development, threatening long-term ability to treat disease effectively. Intensive aquaculture systems create disease pressure that drives antibiotic reliance. Systems that invest in biosecurity, vaccination, and lower stocking densities reduce disease incidence and antibiotic need, achieving better welfare outcomes through prevention rather than treatment.