Hyperadrenocorticism (Cushing disease) is one of the most common hormonal disorders in middle-aged to older dogs, causing widespread symptoms that significantly affect quality of life.
Cushing disease causes chronic, multisystemic effects that progressively impair quality of life. Affected dogs experience constant thirst and frequent urination disrupting normal routines, muscle weakness that limits activity, skin fragility leading to wounds, and susceptibility to infections. The gradual onset often means dogs suffer for extended periods before diagnosis. Many owners attribute early signs to normal aging, delaying treatment. With proper diagnosis and management, most dogs can have significantly improved quality of life, though treatment requires lifelong medication and frequent veterinary monitoring. The welfare burden of unrecognized or undertreated Cushing disease is considerable given the number of dogs affected.