Cat Polycystic Kidney Disease Screening

Polycystic kidney disease is a hereditary condition common in Persian and related breeds. DNA testing and selective breeding can eliminate the disease.

Key Facts

PKD is caused by a dominant genetic mutation causing fluid-filled cysts to develop in kidney tissue
Prevalence in Persian cats has historically been very high, estimated at 30-40% in some populations
DNA testing identifies carriers and affected cats with 100% accuracy for the known mutation
Cysts develop progressively from birth, causing kidney failure typically in middle age
Many countries now require PKD-negative status for registration of Persian kittens with breed societies

Welfare Considerations

Cats with PKD experience progressive kidney function loss leading eventually to chronic kidney disease with all its associated suffering including nausea, lethargy, and weight loss. The condition is entirely preventable through genetic testing and breeding from negative cats only. Continued production of PKD-affected kittens by breeders who do not test represents a welfare failure. Consumer demand for DNA-tested kittens and breed society registration requirements are the most powerful levers for elimination.

What You Can Do

Only purchase Persian or related breed kittens from breeders who DNA test for PKD
Ask to see the DNA certificate before purchasing a kitten
Support breed societies that require PKD-negative status for registration
Rescue organisations offer PKD-tested rehomed cats as alternatives to buying kittens
Encourage awareness of PKD testing in Persian cat owning communities