Hyperadrenocorticism (Cushing's disease) in dogs is a chronic endocrine disorder causing progressive welfare deterioration that requires careful long-term management and monitoring to maintain quality of life.
Cushing's disease causes chronic welfare impairment through multiple mechanisms: the classic polydipsia and polyphagia create constant thirst and hunger that is distressing; muscle weakness causes difficulty rising and exercising; thin, fragile skin leads to bruising and poor wound healing; and the pot-bellied appearance reflects genuine abdominal muscle weakness affecting mobility. Without treatment, progressive cortisol excess causes serious secondary conditions including hypertension causing blindness, diabetes, and blood clots in the lungs. Treatment with trilostane significantly improves quality of life in well-controlled dogs, but requires regular ACTH stimulation testing for safe dose management. Close owner-vet partnership is essential for optimal long-term welfare outcomes.