The red squirrel has been displaced from most of England and Wales by the introduced grey squirrel, which outcompetes reds and carries squirrelpox virus to which reds have no immunity.
Red squirrel conservation involves direct welfare trade-offs: lethal grey squirrel control prevents squirrelpox transmission and competitive displacement, but causes the death of sentient animals. Individual grey squirrels trapped and killed for conservation suffer real harm. The welfare case for control rests on the much larger scale of red squirrel suffering from squirrelpox — a fatal viral disease that causes distressing clinical signs including facial swellings, ulceration, and death within 15 days. Humane trapping methods and rapid killing techniques minimise grey squirrel suffering. The development of immunocontraception for grey squirrels would represent a major welfare improvement if effective in field conditions.