Horse Cushings Disease: Long-term Medication Management

Pituitary pars intermedia dysfunction (PPID) in horses requires lifelong management. Early diagnosis and treatment prevent serious complications.

Key Facts

PPID affects up to 25% of horses over the age of 15
It is caused by dysfunction of the intermediate pituitary gland
Classic signs include hypertrichosis — failure to shed the winter coat
Pergolide mesylate is the only licensed treatment and is highly effective
Unmanaged PPID increases risk of laminitis, muscle wastage and infection

Welfare Considerations

Horses with untreated PPID suffer from the secondary consequences including severe laminitis, recurrent infections and generalised debilitation. The chronic nature of the disease means welfare depends entirely on owner commitment to daily medication and monitoring. Seasonal ACTH fluctuation in autumn means blood tests should be interpreted against seasonally adjusted reference ranges. Owners who understand the disease and maintain regular veterinary oversight achieve the best long-term welfare outcomes.

What You Can Do

Request an ACTH blood test if your older horse shows coat changes or recurring laminitis
Give pergolide medication daily without interruption to maintain control
Test ACTH levels in autumn using seasonally adjusted reference ranges
Work with your farrier and vet together if laminitis is a complication
Monitor body condition, muscle score and comfort indicators monthly