Horse Metabolic Testing and PPID Welfare

Pituitary pars intermedia dysfunction (PPID, formerly Cushings disease) is common in older horses and ponies. Early diagnosis and treatment dramatically improves welfare outcomes.

Key Facts

PPID affects an estimated 21% of horses over 15 years old
The condition causes hypertrichosis (long curly coat), muscle wasting, and laminitis
Laminitis associated with PPID is extremely painful and a leading cause of euthanasia
The ACTH blood test is the most reliable diagnostic tool for PPID
Pergolide medication can significantly improve quality of life when started early

Welfare Considerations

PPID causes progressive deterioration in horse welfare through multiple mechanisms. Abnormal cortisol regulation leads to muscle loss, immunosuppression, increased susceptibility to infection, and the development of laminitis. The classic hypertrichosis causes thermoregulatory problems in warm weather. Most significantly, laminitis in PPID horses can be severe and unrelenting. Early diagnosis through annual ACTH testing of horses over 15 years allows treatment before serious complications develop. Many horses on appropriate pergolide treatment enjoy significantly improved quality of life.

What You Can Do

Request annual ACTH testing for horses over 15 years old
Clip affected horses in summer to prevent heat stress
Work with your vet to implement dietary management appropriate for PPID
Start pergolide treatment promptly if PPID is diagnosed
Monitor closely for signs of laminitis and seek urgent treatment if suspected
Provide appropriate dental care as PPID horses develop dental problems