Splint formation from periostitis of the cannon and splint bones causes acute lameness that typically resolves with appropriate management, but requires patient welfare support during the active phase.
Active splint formation causes genuine pain from periosteal inflammation — the periosteum (bone covering) is densely innervated and inflammation here causes significant, constant discomfort. A horse with active splint may show marked lameness that horses in the acute phase often mask partially through stoic behavior but reveal on nerve block or through subtle alterations in posture. Rest from work during the active phase is both welfare-positive and prognostically beneficial — horses who continue in work during active splint formation experience prolonged pain and may develop larger, more problematic growths.