Protein-losing nephropathy in dogs causes progressive kidney failure through protein leakage into the urine, requiring early detection and aggressive management to slow progression.
PLN causes progressive chronic kidney insufficiency that affects energy levels, appetite, and comfort over months to years. Fluid accumulation from hypoalbuminemia causes swollen limbs and breathing difficulties in advanced cases. The gradual nature of the disease means dogs endure prolonged reduced wellbeing before diagnosis in many cases. Breed-specific screening in Wheaten Terriers and Bernese Mountain Dogs can detect protein leakage early, when intervention is most effective.