Cat Eosinophilic Granuloma Complex

Eosinophilic granuloma complex is a group of inflammatory skin conditions in cats often driven by allergies and immune dysregulation.

Key Facts

EGC comprises three conditions: eosinophilic plaques, eosinophilic granulomas, and indolent ulcers
Lesions occur most often on the lip, abdomen, inner thighs, and oral cavity
The underlying cause is usually allergy - flea allergy, food allergy, or environmental allergens
Eosinophilic plaques are intensely pruritic; granulomas are firm raised lesions; indolent ulcers are painless
Diagnosis is often clinical but biopsy confirms when presentation is atypical
Treatment targets the underlying allergy plus anti-inflammatory medication for active lesions
Recurrence is common without addressing the root allergic cause

Welfare Considerations

Eosinophilic plaques cause intense itching that leads to self-trauma and significant distress. Oral lesions may impair eating and drinking. The chronic relapsing nature without allergy management means cats experience repeated episodes of discomfort. Identifying and eliminating the allergic trigger is the most effective welfare intervention for long-term quality of life.

What You Can Do

Consult a veterinary dermatologist if your cat has recurring skin lesions despite treatment
Implement strict flea prevention as flea allergy is a common EGC trigger
Consider a dietary elimination trial if flea control alone does not resolve lesions
Follow up on environmental allergy testing for cats with difficult-to-control EGC
Prevent self-trauma with an Elizabethan collar during acute episodes
Monitor for oral lesions that may affect your cat's ability to eat comfortably