Cheetahs have extremely low genetic diversity from historic population bottlenecks, creating health vulnerabilities and complicating captive management.
Cheetah genetic uniformity means that a single novel pathogen could theoretically devastate the entire population simultaneously. Captive cheetah stress from inadequate environments triggers genetic predispositions to liver disease that wild cheetahs with lower chronic stress levels don't express as severely. The interaction between genetics and welfare conditions determines health outcomes. Welfare-improving captive management directly reduces genetic disease expression in this uniquely vulnerable species.