Radioactive iodine (I-131) is the gold standard curative treatment for feline hyperthyroidism, offering a one-time injection that resolves overactive thyroid with minimal side effects.
For cats that tolerate ongoing daily medication poorly - and many do not - I-131 represents a significant welfare improvement. After a hospital stay for radiation safety reasons, most cats return home cured. The welfare trade-off of isolation during hospitalization is typically outweighed by the long-term benefit of thyroid normalization without ongoing stress from daily pilling.