Addison's disease (hypoadrenocorticism) causes dogs to be unable to produce essential stress hormones; it is life-threatening but very manageable with lifelong treatment.
Dogs with undiagnosed Addison's experience episodic crises that are genuinely life-threatening and acutely distressing. After diagnosis, the welfare picture changes dramatically - with consistent medication, dogs live full, healthy lives. The key welfare challenge is ensuring owners understand to increase steroid dosing during stressful events like illness, surgery, or travel.