Companion Animals

Cat Polycystic Kidney Disease: Genetic Testing and Prevention

PKD is an inherited condition in Persian and related breeds causing kidney cysts that progressively impair renal function; genetic testing can eliminate the disease from breeding lines.

Key Facts

PKD affects approximately 36-49% of Persian cats depending on the population studied
The condition is caused by a single dominant mutation in the PKD1 gene
A simple DNA test can identify affected cats before they develop clinical symptoms
Affected cats develop hundreds of cysts that progressively replace functional kidney tissue
Most affected cats develop chronic kidney disease by 7-10 years of age

Welfare Considerations

PKD causes progressive kidney failure in a substantial proportion of Persian cats - representing a massive preventable welfare burden. Since the causative mutation is known and a simple test exists, there is no ethical justification for continuing to breed PKD-positive cats. The welfare cost of renal failure in cats - including nausea, inappetence, and uremia - is severe and prolonged.

What You Can Do

Only acquire Persian or related breed cats from breeders who test for PKD1 mutation
Ask to see negative PKD test certificates before purchasing or adopting
Support breed clubs that mandate PKD testing as a condition of registration
Advocate for mandatory PKD testing in Persian cat breeding standards globally