Hyperadrenocorticism (Cushing's disease) is a common hormonal disorder in middle-aged and older dogs, causing a range of symptoms that significantly affect quality of life and require lifelong management.
Cushing's disease creates chronic welfare compromise through multiple pathways. The persistent elevated cortisol suppresses immune function, causing recurrent skin and urinary infections. Muscle weakness from protein catabolism affects mobility and the ability to perform normal activities. The pot-bellied appearance reflects abdominal muscle weakness and organ enlargement that is uncomfortable. Extreme polydipsia (water drinking) and polyuria (urination) disrupt sleep and normal behavior patterns. Treatment with mitotane or trilostane carries significant risks of adrenal crisis - a medical emergency requiring immediate intervention. The combination of chronic multi-system effects and treatment monitoring burden creates a significant quality-of-life reduction for affected dogs.