Hyperadrenocorticism (Cushing's disease) is a common hormonal disorder in middle-aged and older dogs that causes progressive multi-system effects compromising quality of life.
Cushing's disease causes insidious, progressive welfare compromise as chronically elevated cortisol affects multiple body systems simultaneously. Dogs experience muscle weakness that affects mobility, skin fragility, poor coat condition, and the discomfort of constant thirst and urination. The pot-bellied appearance reflects muscle wasting and fat redistribution rather than obesity. Secondary complications including recurrent infections and life-threatening thromboembolism represent serious welfare events. The slow progression means dogs may experience significant welfare compromise for extended periods before diagnosis. Medical treatment substantially improves clinical signs and quality of life, though lifelong monitoring is required and medication dosing must be carefully managed to avoid adrenal crisis from over-treatment.