Hyperadrenocorticism (Cushing's disease) in dogs causes chronic hormonal imbalance producing multiple welfare-impairing symptoms that require long-term management with monitoring for treatment-related complications.
Cushing's disease causes a cluster of welfare-impairing symptoms: constant thirst and urination disrupting normal behavioral routines, insatiable hunger creating chronic frustration when food access is controlled, progressive muscle weakness limiting activity, and the social changes associated with hair loss and skin changes. Dogs with advanced disease are also prone to panting discomfort, abdominal distension, and skin infections. Treatment with trilostane improves quality of life for most dogs but requires careful monitoring - over-suppression of adrenal function causes acute adrenal crisis that can be life-threatening. Welfare-centered Cushing's management balances symptom control against treatment risk through regular monitoring and owner education.