Mastitis is the most costly and welfare-significant disease in dairy cattle, causing painful udder inflammation that affects millions of cows annually in dairy systems worldwide.
Dairy cows with mastitis experience painful inflammation of their udders that causes reluctance to be milked, altered gait to protect the affected quarter, and reduced feed intake from systemic illness. Subclinical mastitis, which causes no obvious swelling but significant inflammation, represents a vast reservoir of undetected chronic pain in dairy herds. The high mastitis prevalence reflects the welfare cost of extreme milk production selection and management systems that prioritize output over health.