Feline calicivirus is a major cause of upper respiratory infection in cats, causing significant suffering in cats worldwide especially in shelters.
Calicivirus causes painful oral ulcers that make eating extremely difficult for affected cats, leading to significant suffering and weight loss. Cats in shelters experience stress that suppresses immunity, making outbreaks more frequent and severe. Virulent systemic calicivirus is particularly alarming - affected cats develop swollen faces, limb edema, and high fever, with many dying despite intensive care. Even recovered cats may become chronic carriers, perpetuating shelter outbreaks. Early identification and isolation, along with supportive care including pain management, are critical welfare interventions.