The history of great ape biomedical research reveals welfare harms on an enormous scale, and the lessons inform current animal research ethics.
The scale of psychological suffering inflicted on socially isolated research chimpanzees over decades represents one of the most significant welfare failures in the history of human-animal relations. Animals capable of complex social bonds, tool use, and emotional expression were confined alone in small cages for their entire adult lives. This history motivates both sanctuary support and ongoing vigilance against welfare regression in animal research policy.