Uterine adenocarcinoma affects the majority of unspayed female rabbits by age 5, making spaying a critical welfare intervention for female rabbit health.
Uterine cancer in rabbits is one of the most preventable welfare problems in companion rabbit care. The prevalence - potentially majority of unspayed females - means that not spaying is a welfare gamble with very poor odds. The cancer causes suffering through hemorrhage, weight loss, and metastatic disease. Finding a rabbit-savvy vet who is experienced with rabbit anesthesia significantly reduces surgical risk. The welfare argument for spaying female rabbits before age 2 is compelling and evidence-based.