Ketosis is a common and painful metabolic disease in dairy cows around calving, with prevention through transition period management being the highest-impact welfare intervention.
Clinical ketosis causes significant suffering through reduced appetite, weakness, and in severe cases neurological signs including abnormal behavior and aggression (nervous ketosis). The cow's general malaise from metabolic dysfunction is comparable to severe human illness affecting every system. Subclinical ketosis, while less dramatic, causes persistent metabolic compromise affecting immune function and reproductive performance for weeks. The high prevalence of subclinical ketosis in many dairy herds - affecting the majority of fresh cows - represents a normalization of metabolic suffering that should be recognized as a significant welfare problem requiring proactive management.