Testicular tumors are the most common neoplasm in intact male dogs, with neutering providing both treatment and prevention of these welfare-significant cancers.
Testicular tumors cause welfare harm through local mass effects, hormone-secreting tumors causing feminization and blood disorders, and the rare metastatic disease. Feminizing Sertoli cell tumors can cause severe bone marrow suppression leading to life-threatening anemia and bleeding disorders. Pain from large tumors is a welfare concern. For the vast majority of affected dogs, prompt castration is curative and the welfare outcome is excellent. Retained testicles should be removed prophylactically given the dramatically elevated tumor risk, as the welfare consequences of Sertoli cell tumors developing in retained testicles can be severe.