Exercise-Induced Collapse in Labrador Retrievers

EIC is an inherited condition in Labradors causing episodic collapse after intense exercise, requiring management to prevent welfare-threatening episodes.

Key Facts

Exercise-induced collapse (EIC) is caused by a mutation in the DNM1 gene
It is inherited as an autosomal recessive trait - two copies of the mutation cause clinical disease
Affected dogs collapse after 5-20 minutes of intense exercise, especially in hot conditions
During episodes, dogs show extreme weakness, inability to stand, and disorientation
Most dogs recover fully within 5-30 minutes of rest
Severe episodes can cause hyperthermia and occasionally death
Genetic testing identifies affected and carrier dogs; breeding carriers to carriers produces 25% affected offspring

Welfare Considerations

EIC episodes are frightening for both dog and owner - a dog that suddenly cannot stand or move is acutely distressed. Repeated severe episodes risk hyperthermia and sudden death. Management by avoiding trigger activities - intense sustained exercise, especially in heat - significantly reduces episode frequency and severity. Genetic testing of breeding dogs and responsible selection against the mutation reduces prevalence in future generations.

What You Can Do

Test Labrador Retrievers intended for breeding for the DNM1 EIC mutation
Learn to recognize the early signs of an episode: wobbliness, hind-end weakness
Stop exercise immediately at the first sign of weakness and cool the dog down
Avoid intense sustained exercise in hot conditions with affected dogs
Discuss appropriate exercise management with your vet to maintain fitness while reducing EIC risk