PLN causes progressive renal damage through protein loss, with disease-specific management significantly improving welfare outcomes compared to generic CKD treatment.
PLN causes progressive welfare decline through multiple mechanisms - hypoalbuminemia causes ascites and edema causing abdominal discomfort, thromboembolism causes acute intense pain, and renal damage causes systemic illness. The condition progresses insidiously without monitoring - UPC measurement is essential for early detection in predisposed breeds. Disease-specific management (RAAS blockade, immunosuppression for immune-complex disease) significantly improves welfare outcomes compared to generic CKD management. Early diagnosis through breed-appropriate screening prevents the worst welfare outcomes.