Horse Cushings Disease Management

Equine Cushing's disease (PPID) is the most common endocrine disorder of older horses and significantly reduces quality of life when unmanaged, but treatment with pergolide is highly effective.

Key Facts

Pituitary Pars Intermedia Dysfunction (PPID) affects an estimated 15-20% of horses over 15 years
Clinical signs include hypertrichosis (long curly coat), muscle wasting, pot belly, increased drinking, and laminitis predisposition
Diagnosis is confirmed by measuring ACTH levels in autumn when seasonal rises can mask the disease
Pergolide mesylate (Prascend) is highly effective at controlling PPID and most horses show significant improvement
Laminitis secondary to PPID is a major welfare concern - PPID management dramatically reduces laminitis risk

Welfare Considerations

PPID-related welfare compromise is pervasive in older horse populations. The chronically elevated ACTH of uncontrolled PPID suppresses immune function, impairs muscle maintenance, and predisposes to potentially devastating laminitis. Many horses with PPID go undiagnosed because their gradually worsening condition is attributed to normal aging. The availability of effective, affordable treatment makes PPID diagnosis and management one of the highest-impact welfare interventions available for senior horses.

What You Can Do

Test senior horses for PPID annually from age 15 - earlier if clinical signs develop
Ensure autumn ACTH sampling uses seasonally adjusted reference ranges to avoid false negatives
Start pergolide treatment promptly - delay allows preventable welfare compromise including laminitis
Work with your vet on annual dose titration to maintain optimal control
Monitor for laminitis risk indicators - digital pulses, coronary band sensitivity, and foot temperature