Mules, the offspring of male donkeys and female horses, are widely used for working tasks globally, combining the hardiness of donkeys with the strength of horses but with distinct welfare needs.
Mule welfare is complicated by the limited species-specific knowledge among veterinarians and handlers who may inappropriately apply horse-based protocols. Mules have different metabolic, hoof, and behavioural characteristics requiring tailored care. Their self-protective tendency to refuse dangerous tasks is a welfare asset, but owners who punish this behaviour undermine the trust relationship and override a safety mechanism. Appropriate training using relationship-based methods that work with mule psychology produces far better welfare outcomes than coercive approaches. Access to mule-specific veterinary and husbandry expertise is important for welfare.