Companion Animals

Horse Cushings Disease and Quality of Life

Pituitary pars intermedia dysfunction (PPID), commonly called Equine Cushings Disease, is the most common endocrine disorder of older horses and significantly affects their welfare if unmanaged.

Key Facts

PPID affects an estimated 15-30% of horses over 15 years of age
The condition is caused by a dysfunction in the pituitary gland leading to excess ACTH production
Classic signs include a long, curly coat (hypertrichosis), muscle wasting, and increased drinking and urination
PPID predisposes horses to laminitis, a severely painful hoof condition
Pergolide medication effectively controls symptoms in most horses when started early

Welfare Considerations

PPID has a major welfare impact because of its association with laminitis - one of the most painful conditions horses experience. Many horses with undiagnosed PPID suffer repeated laminitic episodes before the underlying cause is identified. The disease is progressive and currently incurable, but medical management with pergolide dramatically improves quality of life. Regular screening of horses over 15 years old with an ACTH blood test allows early intervention.

What You Can Do

Screen horses over 15 years old annually for PPID with an ACTH blood test
Learn the signs of PPID including abnormal coat shedding and muscle loss
Work with your vet to optimize pergolide dosing and dietary management for horses with PPID
Support research into equine endocrine disorders and their welfare impacts