Cushing's disease (hyperadrenocorticism) is one of the most common hormonal disorders in middle-aged and older dogs. It significantly impacts quality of life but is manageable with the right care.
Cushing's disease often develops gradually, and owners may attribute early signs to normal ageing. This means affected dogs can experience chronic discomfort - including skin irritation, muscle weakness, and increased vulnerability to infections - for extended periods before diagnosis. The excess cortisol also suppresses immune function, making dogs more susceptible to urinary tract infections and skin conditions. With appropriate trilostane treatment and regular monitoring, many dogs experience dramatic quality of life improvements and manage well for several years.