Prairie dogs are keystone species of North American grasslands facing threats from sylvatic plague and extermination that affect both individual welfare and ecosystem health.
Prairie dogs affected by sylvatic plague die rapidly from septicemia, experiencing fever, weakness, and physiological collapse. Colony-wide plague events cause mass death in tight-knit family groups where individuals maintain complex social bonds. Poisoning campaigns cause slow deaths from anticoagulant rodenticides. Surviving prairie dogs in degraded or isolated colonies lose the social complexity and anti-predator benefits of large groups, experiencing heightened fear and stress.