Feline calicivirus causes oral ulceration and respiratory disease, but virulent systemic strains cause severe outbreaks with high mortality requiring specific welfare interventions.
Typical FCV causes significant discomfort through oral ulceration making eating painful, nasal congestion impairing smell, and lameness. VS-FCV causes extreme suffering with multi-organ involvement and systemic vasculitis. During VS-FCV outbreaks in shelters or catteries, strict isolation, aggressive supportive care, and willingness to euthanise severely affected cats to prevent prolonged suffering are essential welfare decisions. Early recognition of VS-FCV presentations and rapid response significantly reduce suffering.