Feline upper respiratory infection or cat flu is endemic in rescue populations and poses major welfare challenges in shelter environments.
Feline URI causes significant suffering in affected cats: nasal congestion, conjunctivitis, oral ulcers, and fever collectively impair the ability to smell, eat, breathe, and interact normally. Kittens with severe URI can deteriorate rapidly and face a significant mortality risk. The chronic shedding of recovered carrier cats means shelters must manage the tension between preventing isolation-induced psychological harm and controlling disease spread. High-quality shelter medicine including appropriate vaccination, housing design to reduce disease transmission, and prompt identification and treatment of sick cats reduces both disease burden and welfare impacts. Progressive shelters using community cat programmes and foster networks reduce shelter density and disease transmission.