Feline Hypoadrenocorticism: Addisons Disease in Cats

Key Facts

• Feline hypoadrenocorticism is rare but presents with weakness, weight loss, vomiting, and cardiovascular collapse in crisis
• Diagnosis requires ACTH stimulation test showing inadequate cortisol response
• Treatment requires lifelong mineralocorticoid (fludrocortisone or DOCP) and glucocorticoid supplementation
• The prognosis with treatment is excellent — most cats return to completely normal quality of life
• Stress dosing (extra glucocorticoids during illness) prevents Addisonian crises during concurrent disease

Welfare Considerations

Feline hypoadrenocorticism causes severe welfare suffering in acute crisis through cardiovascular collapse and profound weakness. The acute Addisonian crisis is a medical emergency requiring IV fluids, IV hydrocortisone, and intensive supportive care. Once diagnosed and stabilized, the prognosis with lifelong treatment is excellent — most cats are indistinguishable from normal. Owner education about stress dosing is critical to preventing future crises.

What You Can Do

• Seek emergency care immediately for any cat showing profound weakness and cardiovascular instability
• Commit to lifelong daily medication — missing doses risks Addisonian crisis
• Learn to recognize signs of inadequate hormone replacement and adjust dosing with veterinary guidance
• Increase glucocorticoid dose during periods of stress or illness as directed by your vet
• Monitor electrolytes every 6-12 months to ensure mineralocorticoid dosing remains adequate