Feline Polycystic Kidney Disease: Genetic Welfare Burden

Key Welfare Facts

Persian and related breeds have a high prevalence of PKD1 gene mutation causing progressive kidney cyst development.
Cysts replace functional renal tissue over years, causing progressive renal failure by middle to old age.
Affected cats develop chronic kidney disease signs including weight loss, vomiting, and polydipsia over time.
Genetic testing allows identification of affected cats before breeding, enabling elimination from breeding programmes.
PKD is one of the best examples of a welfare problem that can be substantially reduced through breeding practice.
International breeding registers now record test results and some breed clubs require testing before registration.

Welfare Assessment

Feline PKD is a preventable inherited welfare burden that should not be passed to future generations. Purchasing from PKD-tested parents and supporting breed clubs that mandate testing before registration represents the most impactful welfare intervention.

What You Can Do

Only purchase Persian or related breed cats from PKD DNA-tested parents
Support breed club policies requiring PKD testing before breeding registration
Monitor PKD-positive cats with regular renal function assessments from middle age
Advocate for mandatory PKD testing across all affected breeds internationally