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Protein-Losing Nephropathy in Dogs: Advanced Welfare Guide

An in-depth guide to protein-losing nephropathy, covering causes, welfare impacts, and evidence-based management for affected dogs.

Key Facts

PLN causes protein loss through damaged kidney filtration barriers
Dogs develop hypoalbuminaemia, oedema, and risk of thromboembolism
Immune-mediated glomerulonephritis is a common underlying cause
Urine protein:creatinine ratio monitors disease severity and treatment response
Treatment includes immunosuppression, ACE inhibitors, and anticoagulants
Low-protein, omega-3-enriched diets support kidney function and reduce loss

Welfare Considerations and Management

Welfare-centred PLN management addresses both the underlying cause and consequences of protein loss. Immunosuppressive therapy targets immune-mediated glomerular damage. ACE inhibitors reduce proteinuria and slow progression. Anticoagulation (aspirin, clopidogrel) reduces thromboembolism risk. Dietary management with renal diets reduces protein load. Regular monitoring of UPC ratio, albumin, and blood pressure guides treatment. Oedema management improves comfort and mobility.

What You Can Do

Monitor for signs of oedema (swollen limbs, abdomen) and breathlessness
Feed a renal diet with omega-3 supplementation as directed by your vet
Administer anticoagulant medications to reduce clot risk
Regular urine and blood monitoring guides treatment adjustments