Black-tailed prairie dogs are a keystone species of the Great Plains, supporting over 150 other species. Sylvatic plague, introduced from Asia, causes mass mortality events that devastate colonies and threaten dependent species including the black-footed ferret.
Prairie dogs dying from plague experience acute septicaemia with rapid deterioration. Mass mortality events eliminate entire colonies within weeks, causing death of thousands of individuals and cascading welfare harm for dependent predators and scavengers. Burrowing owls that nest in abandoned prairie dog burrows after colony collapse face homelessness. Oral vaccine delivery is a welfare-positive intervention that prevents mass mortality without the stress of individual handling.